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|This article is copyright © Nils Osmar 2019.
- Several supplements have been shown to increase NAD+ levels in the body.
- Some also support the activity of our mitochondria and sirtuin genes.
- Some supplements work by providing the raw materials for making more NAD.
- Others work by preventing enzymes from destroying NAD in our bodies.
Some are cheap; but others are prohibitively expensive. If you rely on supplements alone, you could easily end up spending $5 a day just trying to keep your NAD levels high. But you can keep your NAD levels up without spending very much if you approach it from a different angle.
LIST OF SUPPLEMENTS
- NMN (nicotinamide mononucleotide) I take 750 mg of NMN every day along with resveratrol and some adjunct supplements. It has been shown to lengthen the lifespan of laboratory animals and greatly increase their endurance.
- NR (nicotinamide riboside) The main selling point for NR is that it has the benefits of nicotinic acid but does not raise blood glucose levels or cause flushing. While it does raise NAD levels, NR has been shown to decrease performance in lab animals in some studies. I used to take it but no longer take it or recommend it.
- ALPHA LIPOIC ACID (ALA): Increases SIRT1 activity. Supports high NAD levels.
- PAU D’ARCO (available as a supplement or a tea) Does not raise NAD specifically, but helps convert NADH into NAD+ in the body.
- TRYPTOPHAN (available in several foods) (a niacin precursor) (not particularly effective; you have to take a large amount of tryptophan to produce enough niacin to make a difference.
- MALIC ACID (available in apples and many other fruit.) (similar to Pau D’Arco, in that it participates in the conversion of NADH into NAD+) (More info)
- VITAMIN D (has numerous benefits, including increasing NAD levels)
- LEUCINE (an amino acid found mainly in animal foods such as beef, pork, chicken, but also in some plant foods such as soy.) Raises intracellular NAD levels and supports SIRT1 activity. CAUTION: Foods high in leucine raise mTOR levels. Some mTOR is necessary, and has beneficial effects in the body, but low mTOR levels have been found to promote longevity. If you eat foods high in leucine, try balancing it out by doing fasting or time restricted eating.
- APIGENIN (found in parsley, celery, chamomile, grapefruit and green tea – also available as a supplement) See article
- RUTIN A protein called PARP1 gets hyper-activated during DNA repair, depleting NAD from the body. RUTIN inhibits PARP1, and raises NAD. See article
NAD BOOSTERS I DON’T RECOMMEND TAKING:
- NIACIN (nicotinic acid) Effective, but large amounts can cause flushing, which some people don’t like. Flushing isn’t dangerous, but can be uncomfortable. Also, large amounts taken over time can raise blood glucose, so it’s not recommended for diabetics or prediabetics.) (Some people taking niacin take supplements such as berberine, which lowers blood glucose, along with it.)(Caution: Sustained-release (SR) niacin can cause liver damage if taken in large amounts over a long period of time. Immediate release (IR) niacin has not been shown to cause liver damage.) (May also dampen SIRT1 activity, not a good thing.
- NIACINAMIDE (also known as nicotinamide) (Effective, but some studies suggest that large amounts of niacinamide, taken over time, can dampen SIRT1 activity, inhibiting expression of the the sirtuin genes)
MY REGIMEN (4-5 DAYS A WEEK):
- NMN – 750 MG
- RESVERATROL (600 MG)
- PTEROSTILBENE (100 MG)
- TMG (1,000 MG)
- RUTIN (200 MG)
- ALPHA LIPOIC ACID: 2,000 MG
- TAKEN WITH: PARSLEY JUICE FOR APIGENIN
- COST: ABOUT $5/DAY
In PART 2, I talk more about these supplements — but also about inexpensive or FREE things you can do easily and routinely to keep your NAD levels up, some of which don’t involve food or supplements at all. CONTINUE TO PART 2