ANTI-AGING: SUPPLEMENTS THAT INCREASE NAD+ LEVELS IN THE BODY

 

This article is intended solely for informational purposes. It is not meant to be taken as, and should not be construed, as medical advice. Any changes to your lifestyle or diet should be done in consultation with your doctor or health care professional.

Hello, I’m Nils. In this video I’ll be talking about supplements that have been shown to increase NAD levels in the body.

First a reminder that nothing in this video is intended as, or should be taken as, medical advice. I’m just sharing information hoping it’ll be helpful.

Several supplements have been shown to increase NAD levels in the body. 

Some also support the activity of our mitochondria and sirtuin genes, which goes hand in hand with raising NAD.

David Sinclair has said that NAD is like the gas that makes your car “go.” Sirtuin activators are like the accelerator pedal.

Some supplements work by providing the raw materials for making more NAD. Others work by preventing enzymes from destroying NAD in our bodies, or by helping convert NADH into NAD+.

Some are cheap; others are more expensive. Some may be ones you’re already supplementing with.


NAD-BOOSTING SUPPLEMENTS

NMN (nicotinamide mononucleotide) NMN has been shown to raise NAD effectively and to lengthen the lifespan of laboratory animals and greatly increase their endurance. I usually take 1 gram of NMN every day along with resveratrol and some other supplements.

NR (nicotinamide riboside) Like NMN, NR has been shown to raise NAD levels in. While it does raise NAD levels, NR has been shown to decrease performance in lab animals in some studies. I used to take it but no longer do so.

NA (niacin or nicotinic acid) Niacin is another form of B3, similar to NR and NMN. Like them, it provides the building blocks that NAD is made from. It can cause flushing (hot, prickly skin) due to dilation of the surface blood vessels.

The niacin flush is harmless but many people dislike it. Niacin also raises HDL levels and lowers triglycerides.

One caution: Regular IR (immediate release) niacin appears safe as long as you avoid massive doses. But sustained-release (SR) niacin may cause liver damage if taken over a long period of time. 

The NA form of niacin can also cause blood glucose to drift upward. I take it at night because it helps me sleep. I take berberine and chromium along with it to keep my blood glucose under control, and take a little olive oil with it to activate my sirtuins.

ALPHA LIPOIC ACID (ALA): Increases SIRT1 activity (SIRT1 is an anti-aging sirtuin gene), and supports high NAD levels.

PAU D’ARCO (available as a supplement or a tea) Does not raise NAD specifically, but helps convert NADH into NAD+ in the body.

TRYPTOPHAN (available in several foods) (a niacin precursor) (not particularly effective; you have to take a large amount of tryptophan to produce enough niacin to make a difference. Most find it easier just to take niacin.

MALIC ACID (available in apples and many other fruit.) (similar to Pau D’Arco, in that it participates in the conversion of NADH into NAD+) (More info)

VITAMIN  D (has numerous benefits, including increasing NAD levels)

LEUCINE (an amino acid found mainly in animal foods such as beef, pork, chicken, but also in some plant foods such as soy.) Raises intracellular NAD levels and supports SIRT1 activity.

One caution: Foods high in leucine raise mTOR levels. Some mTOR is necessary, and has beneficial effects in the body, but low mTOR levels have been found to promote longevity.

Some folks who eat foods high in leucine recommend balancing it out by doing fasting or time restricted eating, or exercising hard during the period when your mTOR is high.

APIGENIN (found in parsley, celery, chamomile, grapefruit and green tea – also available as a supplement) (Apigenin stops an enzyme called CD-38 from destroying all of the NAD in your body.

RUTIN A protein called PARP1 gets hyper-activated during DNA repair, depleting NAD from the body. RUTIN inhibits PARP1, so it raises NAD.  See article


OFTEN TAKEN WITH NAD BOOSTERS:

  1. RESVERATROL (activates SIRT1 gene)
  2. PTEROSTILBENE (activates SIRT1 gene)
  3. OLIVE OIL OR AVOCADO OIL (contain Oleic Acid which activates SIRT1 gene) (Make sure it’s real olive or avocado oil, not fake)
  4. TMG (not actually a NAD booster or sirtuin activator, but is often taken along with NR or NMN or NA because all three deplete methyl groups from the body; TMG can restore them)

A NAD BOOSTER I DON’T RECOMMEND:

NIACINAMIDE (also known as nicotinamide) Effective, but some studies suggest that large amounts of niacinamide, taken over time, can dampen SIRT1 activity, inhibiting expression of the sirtuin genes)

Some people dispute these studies, and point to one study that showed that it only inhibits SIRT1 in test tube studies, but supports SIRT activation in the body. But it’s used medically when doctors want to lower sirtuin activation.

So David Sinclair, one of the world’s foremost researchers, has said that he avoids it for this reason. I’d like to see more studies to clear this apparent contradiction up.


MY REGIMEN

I take NAD boosters most mornings. (I’ll have coffee, sometimes with a little cream, then take NAD boosters along with parsley/celery juice for apigenin).

I also take cold showers and do HIIT exercise three days a week to raise NAD levels. Then I take the supplements below. If I’m feeling like taking fewer supplements that day, I’ll just take the first four on the list.

  1. NMN – 1 GRAM
  2. RESVERATROL (500 MG)
  3. OLIVE OIL – 1-2 GRAMS (or a bite of avocado)
  4. RUTIN (200 MG)
  5. PTEROSTILBENE (100 MG)
  6. TMG (1 GRAM)
  7. ALPHA LIPOIC ACID: 1-2 GRAMS
  8. LECITHIN (for phospholipids) (may help with absorption)
  9. CELERY OR PARSLEY JUICE FOR APIGENIN

In PART 2, I talk more about these supplements — but also about inexpensive or FREE things you can do easily and routinely to keep your NAD levels up, some of which don’t involve food or supplements at all. CONTINUE TO PART 2