This article is copyright © Nils Osmar 2019.

    • It’s intended solely for informational purposes. It is not meant to be taken as, and should not be construed, as medical advice.
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A recent study suggests that taking five compounds together – human growth hormonemetforminDHEAvitamin D3, and zinc – can turn back Horvath’s epigenetic clock.

In theory, resetting the clock could add healthy years to a person’s life. If you turn it back two years, according to Dr. David Sinclair, you might (possibly) (theoretically) live two years longer as a result.

Some researchers, such as Peter Attia, are dubious. Attia points out that the study had only nine participants and had poor controls. And at least one of the components they were taking (hGH) can be dangerous under some circumstances, at least when taken alone, due to its association with higher mTOR levels.

Nonetheless, some folks in the anti-aging community have been looking into the possibility of emulating the study.  If you’re interested in doing so, you could try getting prescriptions for hGH and Metformin from your doctor, then take the other compounds as supplements.

Or you could try substituting Berberine for Metformin (they have similar properties), and try raising your hGH by non-pharmaceutical means. Doing so appears to be safer than taking it as a supplement.

One method of raising human growth hormone is fasting. Even skipping dinner (not eating before bed) will raise your levels somewhat. Another method is supplementation, not with hGH, but with amino acids which stimulate the body’s production of it. One study found that you can raise your levels significantly by taking these two supplements together:

  • 1500 mg lysine
  • 1500 mg arginine

Subjects were given lysine and arginine in the amounts shown above, with and without exercising. Their blood levels of hGH were tested 30, 60 and 90 minutes later. 

At 60 minutes, their hGH levels were “significantly elevated” –– but only in the group that had not exercised. Exercise actually negated the benefits of supplementation, in this study.

I’ve decided to try a version of this regimen for a few months. When I say “a version” — it’s actually pretty different, partly because I’m also taking NMN and resveratrol along with a few other supplements. There’s no easy answer as to whether it’s good to take them all together. My plan is to do the following, on days when I’m NOT exercising. 

  • Take lysine and arginine together in the morning when I get up (to start cranking up my hGH levels).
  • Take Berberine (my substitute for Metformin), vitamin D, zinc, and DHEA about an hour later. (I’ll be using DHEA cream instead of the DHEA tablets which were used in the study, because it appears to be better for the liver). (I’ll also be taking some milk thistle extract along with the Berberine.) (NOTE: Metformin has been shown to negate the benefits of exercise. It’s possible that Berberine, which has many of the same effects in the body, could have a similar drawback. That’s another reason I’ll be taking these supplements on non-exercising days.)
  • Wait a few hours, then take NMN and resveratrol along with my lunch.
  • This is not a controlled experiment, just an N=1 exploration to see what happens.  I’m already taking a large number of anti-aging compounds, so there won’t be a way to know, or prove, that any effects I end up experiencing are due to this protocol.   But I’m hoping it’ll be interesting to try.