ANTI-AGING: ARE NAD BOOSTERS (NR AND NMN) DANGEROUS?

 

This article is intended solely for informational purposes. It is not meant to be taken as, and should not be construed, as medical advice. Any changes to your lifestyle or diet should be done in consultation with your doctor or health care professional.

Dr. Rhonda Patrick pointed out in a recent article that there is evidence that NMN may have a protective effect against conditions such as Alzheimer’s. And the increase in NAD levels which NMN facilitates may be protective against some of the other manifestations of aging.

But, according to Patrick, taking NMN also appears to increase the likelihood of at least one type of cancer, at least in animal studies. From the article: “When mice were injected with 500 mg/kg/bw of nicotinamide mononucleotide for 13 days, they exhibited significant increases in precancerous and cancerous lesions in the pancreas.”

Patrick concludes that “augmenting diet with supplements such as nicotinamide mononucleotide to increase NAD+ levels may need to be administered with precision to balance any anti-aging effects with potential harmful pro-tumorigenic effects.”

MY THOUGHTS:

  1. Her article is a good summary, and raises some important concerns.
  2. With that said, it’s worth remembering that the mice were given 500 mg/kg/bw of NMN.
  3. Most people taking NMN are taking 2 mg/kg/bw (i.e, somewhere in the neighborhood of 250 mg total per day). Dave Sinclair, who many look to as their guideline for how much to take is taking about 10 mg/kg/bw (1,000 mg total). Few people can afford to take that much.
  4. So the mice were being given 50 times more NMN, per kg of body weight, than David Sinclair takes, and 200 times more than most people who use NMN are taking every day.
  5. For this reason, I’m not too concerned about the possibility of developing cancer from taking NMN. The amount given the mice is astronomically greater than the amount people who include it in their supplements are taking.
  6. But with that said, if I knew that I already had cancer, I would exercise caution in regards to taking NMN, NR and other NAD boosters. 

ARTICLES IN THIS SERIES:

  1. HOW MUCH NMN TO TAKE
  2. TAILOR YOUR DOSE OF NMN TO YOUR BODY WEIGHT
  3. MY EXPERIENCES TAKING NMN – and BRANDS I RECOMMEND
  4. NMN AND CANCER. (IS NMN DANGEROUS?)